Presented by Geir Kjetil Sandve Elvind Hovig
Geir K Sandve1,2, Sveinung Gundersen3, Morten Johansen4, Ingrid K Glad5, Krishanthi Gunathasan6, Lars Holden7, Marit Holden7, Knut Liestøl1,2, Ståle Nygård8, Vegard Nygaard4, Jonas Paulsen1,4, Halfdan Rydbeck1,3,7, Kai Trengereid1, Trevor Clancy3, Finn Drabløs9, Egil Ferkingstad7, Matúš Kalaš10,11, Tonje Lien5, Morten B Rye9, Arnoldo Frigessi7,12 and Eivind Hovig1,3,4,7
1 Department of Informatics, University of Oslo, Norway
2 Centre for Cancer Biomedicine, University of Oslo, Norway
3 Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Po Box 4950 Nydalen, 0424 Oslo, Norway
4 Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Norway
5 Department of Mathematics, University of Oslo, Norway
6 Department of Medical Biology, Faculty of Health Science, University of Tromsø, Norway
7 Statistics For Innovation, Norwegian Computing Center, Norway
8 Bioinformatics core facility, Oslo University Hospital and University of Oslo, Norway
9 Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Norway
10 Department of Informatics, University of Bergen, Norway
11 Computational Biology Unit, Uni Computing, Norway
12 Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Norway
The immense increase in availability of genomic scale data sets, such as those provided by the ENCODE and Roadmap Epigenomics projects, allows individual researchers to analyze and query relations between genomic tracks at an unprecedented level.
The Genomic HyperBrowser (hyperbrowser.uio.no/test) is an open-ended, Galaxy-based web server for the analysis of genomic track data. Through the provision of several highly customizable components for processing and statistical analysis of genomic tracks, the HyperBrowser opens for a range of genomic investigations, related to e.g. gene regulation, disease association or epigenetic modifications of the genome. A main tool offers a set of 56 descriptive statistics and 20 hypothesis tests on properties of individual tracks and relations between tracks. The HyperBrowser hosts a further 40 purpose-built tools for the broader analysis setting, including tools that support typical needs for generating and customizing genomic track data prior to analysis, as well as tools for visualization and more specialized analysis of genomic tracks.