51st AAPM Annual Meeting
Xiaoyuan Chen, Stanford University, Stanford, CA, 94305-5484, US
For more information about the American Association of Physicists in Medicine, visit aapm.org/
AbstractID: 11893 Title: Inorganic Nanoparticles for Molecular Imaging
Nanotechnology, an interdisciplinary research field involving chemistry, engineering,
biology, medicine, and more, has great potential for early detection, accurate diagnosis,
and personalized treatment of diseases. Molecular imaging refers to the characterization
and measurement of biological processes at the cellular and/or molecular level. It can
give whole-body readout in an intact system, dramatically decrease the workload and
reduce the cost of biomedical research and drug development, provide more statistically
relevant results since longitudinal studies can be performed in the same animals, aid in
early lesion detection in patients and patient stratification, and help in individualized
treatment monitoring and dose optimization.
This talk will exemplify the use of various inorganic nanoparticles for optical imaging,
magnetic resonance imaging, computed tomography, and radionuclide imaging. The
advantages of nanoplatform-based molecular imaging over conventional approaches will
be elaborated. However, several issues, such as biocompatibility, pharmacokinetics,
in vivo targeting efficacy, cost-effectiveness, and acute/chronic toxicity, that limit the
clinical translation and wide spread use will also be discussed.
1. Understand the basics of nanotechnology and molecular imaging
2. Understand the chemistry required for nanoparticle surface modification
3. Understand the pros and cons of inorganic nanoparticles for in vivo imaging.
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