51st AAPM Annual Meeting
Subha Srinivasan, Dartmouth College, Hanover, NH, 3755, US
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AbstractID: 11984 Title: Multi-modality image-guided near infrared spectroscopy:
Optimization and clinical applications
Image-guided near infrared spectroscopy (IG-NIRS) provides deep tissue functional characterization at
high resolution. This approach combines conventional imaging techniques such as MRI and CT with
optical near infrared technologies, giving information directly relating to the vascular and metabolic status
of tissue in-vivo. The resultant estimates of total hemoglobin, oxygen saturation, water, lipids and scatter
provide a window towards understanding the mechanisms of cancer in terms of angiogenesis, hypoxia,
changes in the interstitium and cell organelle structural changes. This type of spectroscopy has been applied
for breast cancer diagnosis and treatment monitoring, as well as image-guided fluorescence in smallanimals.
Optimization of these systems is essential to provide quantitative and accurate spectroscopy. This
optimization encompasses system design for simultaneous multi-modality image acquisition, methods for
intelligently combining spatial anatomical structure from MRI/CT into optical recovery, image
segmentation, visualization and interpretation of novel combined optical and MRI/CT parameters.
This talk will provide an over-view of these aspects of multi-modality imaging as well as results from invivo
1. Understanding the rationale for multi-modality IG-NIRS systems
2. Understanding the type of information and contrast available through these systems
3. Understanding the challenges towards clinical use of these systems.