Here is a field of HeLa cells in 3D. They have been labelled with antibodies to recognise the microtubules (red) the spindle assembly checkpoint protein BubR1 (green) and the DNA in blue. The cell in the centre is entering pro-metaphase, but its got 4 spindle poles, instead of the normal 2. This will cause huge problems for the cell when it attempts to divide. For example, its quite likely that this cell will divide into 3 or 4 cells, instead of 2, with each containing less than the required 23 chromosomes needed to create an identical copy of the original cell.
For more info, see our latest publication in Cell Cycle.
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