Doctor Sam Enright and his geneticist wife, Dorinda, face turmoil in their small town when a dozen adolescent girls show up pregnant at Sam’s office—and they’re all virgins. When their own daughter falls victim to the same fate, the Enrights rush to Homeland Security for answers. As the questions multiply, they realize they’re at the vanguard of a worldwide epidemic. When events escalate, a disparate group of international doctors, scientists, and mothers-to-be are brought together at Dorinda’s genetics lab in Middle America. They race to find the cause and meaning of the mysterious pregnancies, but every discovery reveals a new, worse scenario, leaving humanity's very existence in question.