Delivering a medication to the skin is known as a transdermal application (cream, gel, oil). Although it depends on the type of medication you are using, in the case of hormones, it is usually more effective to use those that are cream based than oral capsules. This is due to the fact that hormones are metabolized in the liver; therefore, when taking a medication orally, you will lose approximately 4/5 of it before it reaches your tissues. This is why you much take 5 times the amount that your body normally requires when using oral medications.
Creams, on the other hand, are absorbed through the skin into an underlying fat layer where it begins circulating into the blood almost immediately. They are more effective because the medication will hit the target tissue before it hits the liver.
This is Dr. Taub's lecture presented at the Annual Meeting of The American Association of Sensory Medicine;
It took place in Newport Beach, California on October 26th, 2006. CME Credits were awarded for physicians.
The physicians in attendance were practicing and academic neurosurgeons, neurologists, orthopedic surgeons, general surgeons, anesthesiologists, internists, family doctors and pain management specialists.
Of historical interest is the fact that the lecture is primarily based on directly stimulating Nitric Oxide production rather than directly supporting the Endothelium, which produces Nitric Oxide in the first place. That was, and still is, the focus of Big Pharma in order to create blockbuster drugs like Viagra, which increase Nitric Oxide in the penis, thereby enhancing blood flow.
It required 5 subsequent years of research for Dr. Taub, in collaboration with David and Deborah Oliphant, to change the focus to supporting the health of the Endothelium itself (the ENDO) as a vital organ that is teeming with life--thereby, effectively creating "natural" Viagra to enhance blood flow to the entire body.