CCNA research projects

  1. “The really ambitious agenda we’ve set for ourselves here is not just to get information out, but to get information in, and to have a type of cycle that allows us always to make the science better by listening to people who use the knowledge we present them with. … We want to make sure that what any given scientist has done is said in a way that is clear enough that any other knowledgeable scientist can understand. Science proceeds by knowing more and more and more about smaller and smaller things, but at a certain point you have to synthesize. You have to put it together. And sometimes the disciplinary that allows us to advance – to know more – is an obstacle to us cooperating.”

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  2. “The early, asymptomatic stage of Alzheimer’s disease (referred to as “pre-clinical AD”) should be responsive to disease modifying therapy. Our objective is to explore these early events in order to identify targets for AD diagnosis, prevention, and treatment. Given our significant preliminary findings, we are focusing our studies on inflammation and trophic factor metabolism, as the AD progresses from pre-clinical to clinical presentation.”

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  3. “One commonality among [Parkinson’s, Frontotemporal dementia, ALS and Alzheimer’s disease] is neuron death. The location of neuron death determines the disease type. Another commonality is protein deposits in dying neurons. … The Chakrabartty Lab has created a tool called STOP, which we can use to identify important components of neurodegenerative diseases and we can then use to target potential therapies.”

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  4. “We’re looking at early synaptic changes in the brain in Alzheimer’s disease. These changes may lead to the discovery of new targets for treatment and new biomarkers for early diagnosis. We’re developing novel models to study the disease, new ways of imaging those models, and looking at the effects of inflammation, amyloid accumulation, and altered metabolism on neuronal cell death.”

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  5. “Recent studies have provided very strong support to the effect that disorders, such as heart disease, diabetes, and high blood pressure negatively affect brain health. Sedentary lifestyle and poor diet – clearly – increase our risk for dementia. And, interestingly, the combination of both sedentary lifestyle and poor diet is worse than either alone. … Up to half the cases of Alzheimer’s disease may be the result of diet and lifestyle-associated disorders. We have a real opportunity here to lower the burden of dementia, including Alzheimer’s disease, in the Canadian population.”

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CCNA research projects


This channel provides a snapshot of the excellent work being conducted by researchers within the Canadian Consortium on Neurodegeneration in Aging (CCNA). Follow us here and visit our website to learn more:

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