Computer Science and Applied Mathematics

Sequencing the Genome and What It Tells Us
Ramesh Hariharan, Strand Life Sciences

The genome of a human comprises 3 billion bases and was sequenced in the early 2000s at a cost of several hundreds of millions of dollars.

Remarkable advances in sequencing technology have now reduced the cost of sequencing a genome to about 10-20K dollars, making it possible for the first time to sequence the genome of many individuals (and of course many organisms). There is a distinct possibility that the cost of sequencing may go down to about a thousand dollars which conjures up visions of sequencing being adopted on a personal scale.

The genomes of any two individuals are different (to the tune of about
0.1%) and the goal of large scale sequencing is to identify how these variations correlate with disease. The task of processing genomes to identify variants poses challenges of large data size (one genome is usually a few hundred GBs) and needs specialized algorithms and software systems.

This talk will introduce the landscape of genome sequencing, describe the large data handling challenges, and finally talk of what we can learn currently from the genome sequence.

# vimeo.com/39864427 Uploaded 121 Plays 0 Comments

Computer Science and Applied Mathematics

Kavli Frontiers of Science PRO

The Kavli Frontiers of Science symposium series is the National Academy of Science’s premiere activity for distinguished young scientists. Unlike meetings that focus on a narrow area of science, these meetings allow participants to explore innovative…


+ More

The Kavli Frontiers of Science symposium series is the National Academy of Science’s premiere activity for distinguished young scientists. Unlike meetings that focus on a narrow area of science, these meetings allow participants to explore innovative research ideas across a wide variety of fields and to develop new networks that will serve them as they progress in their careers..

Browse This Channel

Shout Box

Heads up: the shoutbox will be retiring soon. It’s tired of working, and can’t wait to relax. You can still send a message to the channel owner, though!

Channels are a simple, beautiful way to showcase and watch videos. Browse more Channels.