Medical Science

Epitope-based Immunome-derived Vaccines: A Strategy for Improved Design and Safety
Timothy J. Messitt (1), Matthew Ardito(1), Leonard Moise (1,3), William Martin (1), Anne S. De Groot1 (2,3)

(1) EpiVax, Inc. Providence, RI, (2) Brown Alpert School of Medicine, Providence, RI, (3) Institute for Immunology and Informatics, University of Rhode Island, Providence, RI

Summary: Vaccine science has extended beyond genomics and proteomics to also encompass “immunomics”, the study of the universe of pathogen-derived or neoplasm-derived peptides that interface with B and T cells of the host immune system. It has been theorized that effective vaccines can be developed using the minimum essential subset of T and B-cell epitopes that comprise the “immunome”. We and other researchers are therefore using bioinformatics sequence analysis tools, epitope-mapping tools, microarrays and high-throughput immunology assays to discover the minimal essential components of the immunome beginning with genomic data. The genome-to-vaccine strategy may have a significant advantage over conventional vaccines, as careful selection of vaccine components may diminish undesired side effects as have been observed with whole pathogen and protein subunit vaccines.
New approaches to improving vaccine safety and efficacy are needed to prevent and treat infectious diseases and cancer. The genome-to-vaccine strategy to produce epitope-based vaccines is a novel approach that addresses both these needs and is technologically advancing steadily toward licensure of this new vaccine class. This presentation will bring to the fore the critical parameters that vaccine developers need to know to harness genomic data to rapidly progress from pre-clinical testing to clinical trials.
What the audience will gain from the presentation: The audience will learn about:
(1) computer-driven vaccine design using state-of-the art informatics tools, (2) validation of epitope-based immunome-derived vaccines in animal models, (3) the impact of cross-reactive epitopes (heterologous immunity) on immunome vaccine design, (4) how to predict vaccine immunogenicity based on individual HLA types

Background Review Article:
Genome-derived vaccines. De Groot AS, Rappuoli R. Expert Rev Vaccines. 2004 Feb;3(1):59-76.

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Medical Science

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  • Prügivedu

    interesting videos, thanks for sharing all this stuff

    by Prügivedu

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