Medical Science

Human Liver Chimeric Mice in Biomedical Research
Karl-Dimiter Bissig, Baylor College of Medicine

Understanding human disease and developing effective therapies has been one of the oldest desires of mankind. Only over the past few decades have improved tissue culture techniques and enhanced knowledge of mouse genetics allowed us to come closer to this goal by mastering disease modeling. Nevertheless, many disorders are specific to humans and cannot be recapitulated in a tissue culture dish. For example, hepatitis B and C virus infect only humans and chimpanzees and only in a living organism, not in tissue culture. We can tackle this experimental deficit by exploiting our knowledge of mouse genetics to generate human liver chimeric mice. These mice can be repopulated with human liver cells that expand and replace their murine counterparts, so that eventually up to 95% of the liver is of human origin. This humanized liver is sensitive to human viruses and demonstrates many typical characteristics of human liver. These mice are not only useful for infectious disease but also for cancer, human drug metabolism or regenerative medicine. Their ability to accurately mimic human (patho)physiology is leading to their wider adoption in preclinical studies.
Human chimeric mice have been developed for many other organ systems and have become an important, emerging tool for biomedical research.

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Medical Science

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  • Prügivedu

    interesting videos, thanks for sharing all this stuff

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