Neuroscience

Dissecting the Neural Circuits Mediating Anxiety
Kay Tye, The Picower Institute for Learning and Memory

Anxiety disorders are the single most-common class of psychiatric diseases, afflicting up to 28% of the adult population. Although human imaging studies have implicated the amygdala in anxiety, little is known about the functional role of individual microcircuits and distal circuits in terms of their individual contributions to anxiety. Optogenetics, the use of genetically-encodable, light-activated proteins that can be used to depolarize or hyperpolarize cell membranes, is a quickly-growing field. We developed optogenetic projection-specific targeting, electrophysiological and imaging techniques to parse the different circuit contributions, and we apply this multidisciplinary approach to provide a more complete view of how amygdala interactions with the rest of the brain can govern anxiety-related behaviors.

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Neuroscience

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This channel contains session presentations that cover neuroscience topics from the Kavli Frontiers of Science symposium series of the National Academy of Sciences.

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