1. Interferon Therapy in HIV-1 Patients: Detailed Version

    05:14

    from The Wistar Institute / Added

    62 Plays / / 0 Comments

    Luis Montaner, D.V.M., D.Phil., explains the results of a clinical trial trial that suggests interferon can help suppress HIV-1 levels in patients who have suspended their routine antiretroviral therapy. (5:14 min.)

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    • Interferon Therapy for HIV-1 Patients: Short Version

      01:02

      from The Wistar Institute / Added

      95 Plays / / 0 Comments

      Luis Montaner, D.V.M., D.Phil., announced the results of a clinical trial that suggests interferon can help suppress HIV-1 levels in patients who have suspended their routine antiretroviral therapy. (1.02 minutes)

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      • Saquinavir-1ohr

        00:58

        from Edgar Meyer / Added

        5 Plays / / 0 Comments

        Viracept (Saquinavir, Invirase) was designed on the basis of the structure the target enzyme, which mediates maturation of viral particles. When Viracept became available in 1995, the death rate from AIDS fell precipitously: http://www.nigms.nih.gov/Education/structure_drugs.htm Moreover, this historical event proved the undisputed merit of Structure-based Drug Design.

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        • Viracept

          00:56

          from Edgar Meyer / Added

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          Viracept (Saquinavir, Invirase) was designed on the basis of the structure the depicted enzyme, which mediates maturation of viral particles. When Viracept became available in 1995, the death rate from AIDS fell precipitously: http://www.nigms.nih.gov/Education/structure_drugs.htm Moreover, this historical event proved the undisputed merit of Structure-based Drug Design. Here, the enzyme is depicted as a bronze sculpture in the Grand Canyon. The video demonstrates how a sculpture of a molecule would appear in a public space.

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          • 1OHR - target for the design of antiviral drugs

            00:52

            from Edgar Meyer / Added

            6 Plays / / 0 Comments

            Viracept=Saquinavir was designed on the basis of the structure of this enzyme, which mediates maturation of viral particles. Upon its availability beginning in 1995, the death rate from AIDS fell precipitously: http://www.nigms.nih.gov/Education/structure_drugs.htm Moreover, this historical event proved the undisputed merit of Structure-based Drug Design. Here, the enzyme is depicted as a bronze sculpture in the Grand Canyon.

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            • Live Cell Imaging of Retroviral Entry: Video 1

              00:12

              from Annual Reviews / Added

              A video from the 2014 review by Amy E. Hulme and Thomas J. Hope, "Viral Manipulation of Plant Host Membranes," from the Annual Review of Virology: http://www.annualreviews.org/doi/abs/10.1146/annurev-virology-031413-085502?utm_source=vimeo&utm_medium=vi.hulme&utm_campaign=suppvideo Detection of viral fusion with live cell imaging. The fusion of Tomato-Vpr/iGFP-labeled HIV-1 with CHO cells was imaged at 37°C under a blood/gas mixture of CO2 on a DeltaVision OMX microscope. The experiment was imaged for 44 min with a Z series of images taken every 45 s. Viral fusion was observed as a decrease in GFP fluorescence after 37.5 min due to release of the fluid phase GFP marker into the cytoplasm of the cell. The Tomato-Vpr-labeled virus retained a lower amount of GFP fluorescence after fusion due to GFP localization to the interior of the capsid (Figure 1). See Figure 2 for further details.

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