1. Ebola Vaccines: A Rapid Response

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    from WUSTL Public Health / Added

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    This talk from Adrian V.S. Hill, PhD, professor of human genetics and director of the Jenner Institute at Oxford University. He visited Washington University in St. Louis and offered this talk on April 21, 2015.

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    • Measles: the journey of one outbreak

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      from ECDC / Added

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      In just one outbreak, 64 people caught measles in eight different regions across Slovenia, Italy and Belgium in less than eight weeks. The outbreak started at an international dog show in Vrtjoba/Šempete, western Slovenia at the beginning of November 2014. Thirty-six people were initially infected (primary cases), who went on to infect nine others (secondary cases), who in turn infected 16 more (tertiary cases). Measles is more infectious than you think. Source data from Eurosurveillance (http://bit.ly/1Nl68eS & http://bit.ly/15DDlkD), http://www.iss.it and http://www.nijz.si.

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      • Developing New Anti-Virulence Strategies Against Mycobacterium tuberculosis

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        from WUSTL Public Health / Added

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        Christina Stallings, PhD, is an assistant professor of molecular microbiology at Washington University. She offered this talk as part of the Global Health & Infectious Disease Conference on April 10, 2015 at Washington University in St. Louis. The ability of Mycobacterium tuberculosis (Mtb) to withstand antibiotic treatment and host immune pressure has led to a worldwide epidemic of persistent Mtb infection. In order to define ways to target persistent Mtb, in vitro models of mycobacterial persistence must be developed. Toward this end, we have implemented mycobacterial biofilm formation as an in vitro model of persistence since the characteristics of Mtb within a biofilm recapitulate many of the features of bacteria during chronic infection, including stress resistance and antibiotic tolerance. Using this model, we have identified a family of structurally related small molecules with potent anti-biofilm activities in Mtb and have named these compounds MBIs for Mycobacterial Biofilm Inhibitors. Treatment with MBIs restrains the bacteria in a drug-sensitive state where they can be more effectively killed by reactive oxygen species and the drug isoniazid, a key component of anti-tuberculosis therapy that is otherwise ineffective against persistent bacteria. Investigations into the effects of MBIs on Mtb physiology revealed a newly described lipid maturation profile associated with biofilm formation that also occurs during infection and is inhibited by MBI treatment. This work reveals new aspects of Mtb physiology and identifies potential ways to target protective processes employed by persistent Mtb.

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        • Leveraging Impact at Scale in Global Health- Conundrum and Opportunity in Infectious Disease Prevention and Control

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          from WUSTL Public Health / Added

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          Wolfgang Munar, MD, is a senior scholar at Washington University’s Brown School and the associate director of the Global Health Center. He offered this talk as part of the Global Health & Infectious Disease Conference on April 10, 2015 at Washington University in St. Louis.

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          • Risk of Developing TB Disease in Infants Vaccinated with BCG

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            from WUSTL Public Health / Added

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            Helen Fletcher, PhD, works at the London School of Hygiene and Tropical Medicine as an Assistant Professor/Senior Lecturer in Immunology. She offered this talk on April 10, 2015 at the Global Health & Infectious Disease Conference at Washington University in St. Louis. Despite the global use of the bacillus Calmette-Guérin (BCG) vaccine, there are 9 million new cases of tuberculosis (TB) each year and an urgent need for improved vaccines. Better understanding of the risk of development of TB is important for the design of improved vaccines. Samples collected during clinical TB vaccine trials for the investigation of antigen-specific immune responses may be used for the identification of immune mechanisms of TB susceptibility. ] In a series of studies we have found that an increased frequency of myeloid cells is associated with reduced capacity to control mycobacterial growth in vitro and that in clinical cohorts a high frequency of monocytes is associated with risk of developing TB disease. Using stored PBMC from infants enrolled into a Phase IIb efficacy trial of the viral vector vaccine MVA85A (a candidate TB vaccine), we have further explored immune responses in case and control infants to identify immune correlates of TB disease risk. Understanding why TB vaccination fails to protect in endemic populations will help guide the development of more effective vaccination strategies in the future.

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            • Immunity Therapy Center

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              from Immunity Therapy Center / Added

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              If you are suffering from cancer or an autoimmune, degenerative, or infectious disease, we’re glad you found Immunity Therapy Center. Learn more about our doctor and our team, the diseases we treat, and the effective, natural treatments we use.

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              • 2015-02-17 03 Sally Gilbert

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                from Pascale Otis / Added

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                Sally Gilbert is the Manager, Enviornmental & Border Health, Ministry of Health. Sally has considerable expertise in disease surveillance and health system management. She is a national leader in environmental health policy and programme development, with a particular focus on border health protection, emergency management, and drinking-water quality, non-ionising fields, and other health protection issues...

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                • 2015-02-17_Michelle Balm

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                  from Pascale Otis / Added

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                  Michelle Balm is a Clinical Microbiologist and Infectious Diseases Physician at Aotea Pathology and Capital and Coast District Health Board. Michelle has special interests in the epidemiology and control of infectious diseases especially multidrug resistant organisms, emerging viral infections and innovative diagnostic methods including molecular diagnostics.

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                  • Vaccines: An Unhealthy Skepticism

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                    from The New York Times - Video / Added

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                    An outbreak of measles that started at Disneyland has turned a spotlight on those who choose not to vaccinate their children. How did we get to a point where personal beliefs can triumph over science? Produced by: Retro Report Read the article: http://nyti.ms/1KjV9y0 Click here to follow us: vimeo.com/newyorktimes Watch more videos at: nytimes.com/video Follow on Twitter: twitter.com/nytvideo

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                    • Public Health Laboratories Protect You 24/7

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                      from APHL / Added

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                      http://www.APHL.org APHL's developed this public service announcement (PSA) to explain role of public health laboratories in protecting the public from infectious diseases such as Ebola. Aired on a screen in Times Square in New York City, the PSA has run since Thanksgiving Day, 4-5 times an hour, 18 hours a day on the 42nd Street screen (26’ x 20’). It will run on this screen through the end of January, and then again February 1- March 31 on a larger multi-story screen which wraps around the corner at 1500 Broadway and 43rd Street West. The screen is located between the NASDAQ and ABC studios.

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