1. Konstantin Kuteykin-Teplyakov - Molecules of Mysticism: Pharmacology meets Anthropology

    46:55

    from OPEN Foundation / Added

    521 Plays / / 0 Comments

    Molecules of Mysticism: Pharmacology meets Anthropology by Konstantin Kuteykin-Teplyakov, Ph.D. “Molecules of mysticism” are chemical substances that are able to induce mystical experience, increasing the feeling of closeness to the god (entheogens) or to other people (empathogens). It is quite likely, that every mystical experience is mediated chemically, either by some substances of external origin, or by endogenous molecules produced directly in the brain. Some of such mind-altering agents have been used by human beings since thousands of years and had been successfully integrated in the culture, and many other molecules have been discovered over last 50 years thank to progress in neuroscience and psychopharmacology. There are plenty of chemical structures, associated with entheogenic and empathogenic properties, and their action involves release of other neurotransmitters, binding to many brain receptors (5-HT2a, 5-HT2c, 5-HT1a, CB1, NMDA, mAChR etc.) followed by activation of several signal transduction pathways and alterations in gene transcription profile. Additionally, the mechanisms of several adverse effects for entheogens and empathogens have been elucidated during last years. Considering that “molecules of mysticism” works not only and not so much on body level, but mainly on consciousness and behavior, and given the intrinsic difficulties associated with lab-based studies of scheduled substances on human beings, the methods of social anthropology (observation during fieldwork, surveys, interviews and analysis of reports) might be used to supplement the classical pharmacological methodology. Web2.0 approach, based on content generated by users (like forums, wikis, online-based databanks of “trip reports”, multimedia-sharing services etc.), also may serve as valuable tool and information source to study the relationship between drugs and humans. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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    • Peter Oehen - MDMA-Assisted Psychotherapy - Method and Current Research

      55:44

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      MDMA-Assisted Psychotherapy - Method and Current Research by Peter Oehen, MD. Attempts to boost the effectiveness of psychotherapy by combining it with psychotropic medications such as antidepressants or anxiolytics have shown rather limited effects and acute gains have tended to be lost when the drug is discontinued. In recent years, however, there has been growing interest in studying pharmacological interventions that may boost the effectiveness of psychotherapy not by treating symptoms directly but by catalyzing the psychotherapeutic process itself. These approaches use isolated doses of drugs in conjunction with psychotherapy sessions rather than ongoing daily drug doses. Thus, after a hiatus of over 20 years, “psychedelic” compounds such as MDMA or psilocybin are once again becoming subjects of serious, well controlled clinical studies. This presentation will illustrate the neurophysiological and –psychological rationale of MDMA-assisted psychotherapy for PTSD, as well as the nature of the therapeutic process with clinical vignettes. Outcome data from the completed US and ongoing Swiss studies will be presented, which suggest a promising future for this model of drug-assisted psychotherapy. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.stichtingopen.nl www.mindalteringscience.com

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      • Torsten Passie - Astonishing Similarities of Physiological and Psychoactive Drug Induced States

        38:47

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        Astonishing Similarities of Physiological and Psychoactive Drug Induced States by Torsten Passie, MD. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.stichtingopen.nl www.mindalteringscience.com

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        • Katharina Kirchner - LSD-Assisted Psychotherapy - First Results from the Swiss Follow Up Study - PART 2/2

          29:22

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          392 Plays / / 0 Comments

          LSD-Assisted Psychotherapy - First Results from the Swiss Follow Up Study by Katharina Kirchner, MSc. After more than 40 years the first study employing LSD in psychotherapy is being conducted in Switzerland. 12 persons suffering from a life-threatening disease and an anxiety disorder are having the possibility to receive 200 µg of LSD in a therapeutic setting. This talk will present the methodology and set-up of the study lead by Dr. P. Gasser. Furthermore the results from the pilot interviews of the follow-up study will be debuted. The interviews were conducted approximately one year after finishing therapy and were aimed to reveal effects on daily life and long-term changes. Even though it is too early to make generally valid statements, first impressions from the client-centered research give valuable ideas for further research and indicate potential problems. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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          • Katharina Kirchner - LSD-Assisted Psychotherapy - First Results from the Swiss Follow Up Study - PART 1/2

            29:59

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            338 Plays / / 0 Comments

            LSD-assisted Psychotherapy - First Results from the Swiss Follow Up Study by Katharina Kirchner, MSc. After more than 40 years the first study employing LSD in psychotherapy is being conducted in Switzerland. 12 persons suffering from a life-threatening disease and an anxiety disorder are having the possibility to receive 200 µg of LSD in a therapeutic setting. This talk will present the methodology and set-up of the study lead by Dr. P. Gasser. Furthermore the results from the pilot interviews of the follow-up study will be debuted. The interviews were conducted approximately one year after finishing therapy and were aimed to reveal effects on daily life and long-term changes. Even though it is too early to make generally valid statements, first impressions from the client-centered research give valuable ideas for further research and indicate potential problems. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.stichtingopen.nl www.mindalteringscience.com

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            • Anwar Jeewa - An Exploratory Study of the Short-term Effects of Ibogaine Treatment on Drug Addicts - PART 1/2

              15:53

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              302 Plays / / 0 Comments

              An Exploratory Study of the Short-term Effects of Ibogaine Treatment on Drug Addicts by Dr. Anwar Jeewa It has become increasingly difficult to assist an individual to maintain long term recovery from substance abuse. This is frustrating to individuals, their families and also to service providers. The reason for this trend is not absolutely clear. Over the past decades the topic of Ibogaine has been one of active interest for many psychiatrists, neuropsychologists, spiritualists, and especially those involved in drug rehabilitation therapies and alternative healing modalities. It is for this reason that Ibogaine usage on drug addicts compared to those seeking a psycho-spiritual experience has been initiated. The following information is based on the demographic profile of those administered Ibogaine in the course of time spanning from January 2006 to June 2010 by Dr. Anwar Jeewa and staff. The major considerations taken are the gender, nationality, age- range and drug history and the psycho – spiritual effects. All information is based on the Screening Questionnaire of the Ibogaine Treatment Center CC which was directly provided by the client him/herself The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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              • Anwar Jeewa - An Exploratory Study of the Short-term Effects of Ibogaine Treatment on Drug Addicts - PART 2/2

                29:28

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                73 Plays / / 0 Comments

                An Exploratory Study of the Short-term Effects of Ibogaine Treatment on Drug Addicts by Dr. Anwar Jeewa It has become increasingly difficult to assist an individual to maintain long term recovery from substance abuse. This is frustrating to individuals, their families and also to service providers. The reason for this trend is not absolutely clear. Over the past decades the topic of Ibogaine has been one of active interest for many psychiatrists, neuropsychologists, spiritualists, and especially those involved in drug rehabilitation therapies and alternative healing modalities. It is for this reason that Ibogaine usage on drug addicts compared to those seeking a psycho-spiritual experience has been initiated. The following information is based on the demographic profile of those administered Ibogaine in the course of time spanning from January 2006 to June 2010 by Dr. Anwar Jeewa and staff. The major considerations taken are the gender, nationality, age- range and drug history and the psycho – spiritual effects. All information is based on the Screening Questionnaire of the Ibogaine Treatment Center CC which was directly provided by the client him/herself The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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                • Andrew Sewell - Human Psychopharmacology Research at Yale University - PART 2/2

                  25:17

                  from OPEN Foundation / Added

                  84 Plays / / 0 Comments

                  Human Psychopharmacology Research at Yale University by Andrew Sewell, MD. Human psychopharmacology--the experimental administration of mind-altering drugs to human subjects--is an essential tool for characterizing the relationship between brain structure, neurochemistry, and symptomatology. This talk will summarize the last twenty years of completed, ongoing, and planned research at Yale on the drugs ketamine, delta-9-tetrahydrocannabinol (THC), cannabidiol, salvinorin A, dimethytryptamine (DMT), and psilocybin, discussing their use not only as a tool for better understanding human consciousness but also as therapy for specific diseases. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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                  • Andrew Sewell - Human Psychopharmacology Research at Yale University - PART 1/2

                    31:33

                    from OPEN Foundation / Added

                    409 Plays / / 0 Comments

                    Human Psychopharmacology Research at Yale University by Andrew Sewell, MD. Human psychopharmacology--the experimental administration of mind-altering drugs to human subjects--is an essential tool for characterizing the relationship between brain structure, neurochemistry, and symptomatology. This talk will summarize the last twenty years of completed, ongoing, and planned research at Yale on the drugs ketamine, delta-9-tetrahydrocannabinol (THC), cannabidiol, salvinorin A, dimethytryptamine (DMT), and psilocybin, discussing their use not only as a tool for better understanding human consciousness but also as therapy for specific diseases. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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                    • Stephen Snelders - Psychotherapy with Hallucinogens in a Medical Setting: The Shadow of History

                      43:45

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                      156 Plays / / 0 Comments

                      Psychotherapy with Hallucinogens in a Medical Setting: The Shadow of History by Stephen Snelders, Ph.D. In the year 2010 hopeful prospects are attached to psychotherapy with hallucinogens. Attempts are made to bring this kind of therapy out of the confines of illegal subcultures and into legalized medical settings. Discussions and arguments center around medical benefits and are wrapped in the vocabulary of present-day medical and biological sciences. However, medical settings are not ‘neutral’ sctructures’, but are determined by the social and cultural development of medicine and health care and by the load of the past. Advocates and opponents of hallucinogenic therapy alike should be aware of these determinations and take them into account. Hallucinogenic therapy has been practised by doctors from the very first beginning of psychiatry itself, in the early 19th century. It was central to a now controversial tradition of psychopharmacological research and therapy that was qualitative in nature and accorded an inportant place to self-experiences of medical practitioner and patient alike. The problems that face acceptance of hallucinogenic therapy today are both social and political in a wider sense (the load of the revolt of the sixties), as related to the politics of medicine and health care. The Mind Altering Science conference was organized by The OPEN Foundation on 23 and 24 October 2010 at the University of Amsterdam. With researchers and therapists from a wide variety of academic disciplines, this event was dedicated to the exploration of a broad range of subjects. From addiction treatment to psychotherapy with the aid of psychedelics, from the neurobiology of ayahuasca to the social, ritual and legal implications of its use, and from human psychopharmacology research and the exploration of exceptional mind states to new views on the legalization of psychedelic substances. For more information see: www.openfoundation.nl www.mindalteringscience.com

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