1. Optimizing your assays using the Cellometer Vision CBA

    31:55

    from Nexcelom Bioscience / Added

    1 Play / / 0 Comments

    In this training webinar we will look at the Cellometer Vision CBA to help get you more familiar with the instrument’s software. We will then demonstrate many ways to optimize your assays by: creating a new assay; editing existing assays; creating a new cell type; editing an existing cell type; changing the exposure times. We will conclude this training session with a live demonstration in the Cellometer Vision CBA software.

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    • Vienna Research Groups for Young Investigators Call 2010 - Claudine Kraft

      04:47

      from WWTF / Added

      70 Plays / / 0 Comments

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      • President's Lecture: “Your Cells Clean House to Keep You Healthy”

        01:02:33

        from UT Southwestern / Added

        227 Plays / / 0 Comments

        Beth Levine, M.D., Professor of Internal Medicine and Microbiology, and her team explore how fasting activates a cellular process called autophagy, in which cells devour their own damaged or unneeded components. Her laboratory identified the first known gene in mammals that is responsible for autophagy and has since shown that defects in the expression or function of the gene, called beclin 1, may contribute to cancer, aging, neurodegenerative diseases such as Alzheimer’s, and infectious diseases. Dr. Levine discusses her work during the President’s Lecture on April 28, 2011.

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        • How Can We Power-Up Our Immune Systems from the Inside?

          02:25

          from UNM Health Sciences Center / Added

          Autophagy is nature’s way of cleaning house. A team of tiny, autonomous “vacuum cleaners” zip around a cell’s interior, ingesting bits and pieces of worn-out proteins, malfunctioning parts and invading microorganisms. Scientists have begun to figure out this extraordinary process and how vital it is to human health. Vojo Deretic and postdoctoral fellows Michael Mandell and Santosh Chauhan are trying to harness the power of this innate immunity as a potential therapy for a variety of diseases. Deretic and his team have been working on interrelated projects to discover how to encourage autophagy to treat people with dual HIV and Mycobacterium tuberculosis infections. It’s a deadly disease combination, because people with weakened immune systems are more vulnerable to TB’s most severe effects. TB is the leading cause of death among people living with HIV, with co-infection most prevalent in Sub-Saharan Africa. New drug-resistant TB strains are on the rise, further reducing the options available to treat these patients. Mandell and Chauhan have isolated autophagy-specific proteins and molecules that are part of a complex intracellular communication system responsible for making things happen inside the cell. With this new understanding, the team uses high-tech molecular equipment and computational tools to search for FDA-approved drugs that might encourage autophagy to fight infection in a clinical setting. “Every pathogen has its own story,” says Deretic, who began his research career in developmental biology studying sea urchins. “With autophagy, what you have is a general answer to many different question,” he says. “That’s the beauty of it for me.”

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          • 2nd Regional Translational Research-Mitochondria, Aging, and Disease Symposia - Keynote Address - 5:00pm to 6:00pm

            01:03:21

            from UMDF / Added

            31 Plays / / 0 Comments

            Keynote Address: Myc in Mitochondria and Autophagy: Chi Van Dang, MD, PhD, Director, Abramson Cancer Center, University of Pennsylvania

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            • 2nd Regional Translational Research-Mitochondria, Aging, and Disease Symposia - Morning Sessions - 9:45am to 11:15am

              01:31:32

              from UMDF / Added

              53 Plays / / 0 Comments

              Nitrite induces Mitochondrial Fusion to Activate AMP Kinase and Mediate Delayed Cardioprotection After Ischemia/Reperfusion: Sruti Shiva, PhD - Chloroquine Prevents the Development of Hypoxia-Induced Pulmonary Hypertension in Mice by Decreasing Autophagic Flux: Eileen Bauer, PhD - NLRP3 Dependent and Independent Mitochondrial Damage During Inflammasome Activation: Michelle Heid, BS - Rapamcyin improves Survival and Health in a Mouse Model of Leigh Syndrome: Matt Kaeberlein, PhD - Enhanced Autophagy Drives Coordinate Expression in Nuclear and Mitochondrial Genomes: Chad Lerner, PhD - The HMGB1/RAGE Inflammatory Pathway Promotes Pancreatic Tumor Growth by Regulating Mitochondrial Bioenergetics: Rui Kang, MD, PhD

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              • Science Talk: Faulty Clean-up Process May Be Key Event in Huntington's Disease

                03:23

                from Albert Einstein College of Medic / Added

                15 Plays / / 0 Comments

                April 11, 2010 — In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington's disease. Their research is described in the April 11 online edition of Nature Neuroscience. See accompanying release http://www.einstein.yu.edu/home/news.asp?id=480

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