1. ADDF - Dr. Howard Fillit

    18:44

    from World Events Forum, Inc. / Added

    29 Plays / / 0 Comments

    Dr. Howard Fillit's opening remarks at the 9th Annual Drug Discovery for Neurodegeneration Conference held March 1-3, 2015 in San Diego, CA.

    + More details
    • Drugs That Seek Out and Destroy

      02:29

      from Benefunder / Added

      24 Plays / / 0 Comments

      Drug development is a complicated task; scientists must create a drug that binds to its target protein, thus preventing it from performing its function. The problem with this strategy is that eventually the drug falls off the protein, which then frees the protein to work again. Therefore, a patient must take lot of the drug so there are enough drug molecules present to ensure that if one drug falls off the protein, another is available to take its place. The challenge of achieving high enough dose levels to block the function of a protein has resulted in the inability to drug specific diseases. Dr. Craig Crews, of Yale University, is developing a new paradigm for drug development. He and his team's novel approach relies upon drugs that can trick the cell's own quality control mechanisms to remove a target protein completely. Coined the "seek and destroy" strategy by Dr. Crews, this new approach can be applied to diseases such as cancer, autoimmune diseases, and neurodegenerative diseases. Due to the fact that many rogue, disease-causing proteins can not easily be blocked using a small molecule drug approach, Dr. Crews' technique will allow scientists to drug the "undruggable."

      + More details
      • Dr. Marcie Glicksman

        35:30

        from World Events Forum, Inc. / Added

        11 Plays / / 0 Comments

        + More details
        • Bryan Knox

          23:44

          from World Events Forum, Inc. / Added

          7 Plays / / 0 Comments

          + More details
          • Dr. Bruce Molino

            34:25

            from World Events Forum, Inc. / Added

            5 Plays / / 0 Comments

            + More details
            • Dr. D. Martin Watterson

              27:10

              from World Events Forum, Inc. / Added

              5 Plays / / 0 Comments

              + More details
              • Dr. Thomas Chung

                39:32

                from World Events Forum, Inc. / Added

                9 Plays / / 0 Comments

                + More details
                • William Janzen

                  30:02

                  from World Events Forum, Inc. / Added

                  9 Plays / / 0 Comments

                  + More details
                  • Dr. Kalpana Merchant

                    31:28

                    from World Events Forum, Inc. / Added

                    9 Plays / / 0 Comments

                    + More details

                    What are Tags?

                    Tags

                    Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."