1. Market Implications: Coverage and Reimbursement for Molecular Testing

    35:14

    from PMWC Intl / Added

    36 Plays / / 0 Comments

    Speakers: Ira Klein, M.D., Aetna / Sean Tunis, M.D., Center for Medical Technology Policy / Bill McGivney, Ph.D., McGivney Global Advisors / Rina Wolf, XIFIN The application of molecular analyses to guide patient management is now a key component of cancer care. Medicine is working to keep up with the scientific advances, evaluate them, and add molecular tests to guideline and pathway recommendations. The coverage/reimbursement world is working to determine how this emerging, important area should be managed. This session will provide a primer on the basics of coverage and reimbursement and then discuss issues regarding the clinical applications and coverage of molecular testing, evidence thresholds for achieving coverage, reimbursement from both private and public payers, etc.

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    • Molecular Testing Products, Coverage & Reimbursement: Wrestling with Costs and Technology by Ira Klein, Aetna

      11:28

      from PMWC Intl / Added

      14 Plays / / 0 Comments

      Primer on the basics of coverage and reimbursement.

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      • The Power of Companion Diagnostic Testing in Personalized Medicine by An Pang Chieng, WARFARIN Study

        18:09

        from PMWC Intl / Added

        17 Plays / / 0 Comments

        Speaker: An Pang Chieng, M.D., National PI, WARFARIN Study Iverson Genetics is currently performing a study, supported by The Center for Medicare & Medicaid Services, addressing the question of whether or not genetic information can reduce the incidence of bleeding and clotting adverse events associated with the initiation of Warfarin therapy (one of the most problematic medications in our healthcare systems history). The outcome of this study could potentially influence the manner in which new pharmaceuticals are brought to market.

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        • Drug Rescuing with GPScreen, Toxicity Biomarker Discovery & Companion Dx by Han-Oh Park, Bioneer

          12:12

          from PMWC Intl / Added

          37 Plays / / 0 Comments

          Speaker: Han-Oh Park, Ph.D., CEO, Bioneer Corp. Schizosaccharomyces pombe has been an important model system to study cell division and signal transduction mechanism. S. pombe genes are not just highly homologous to human genes but also the pathways are similar. Gene deletion inside a cell is an essential tool to study gene function through phenotype investigation and drug target validation. The completion of the S. pombe genome knockout project resulted in the introduction of a genome-wide drug target screening system, GPScreen™. In this presentation we will discuss how we can utilize GPScreen platform technology in accelerating drug discovery by rescuing and repurposing drugs.

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          • FDA Skin

            00:30

            from Kilt Studios / Added

            FDA Skin is one part of a four spot Anti-Smoking campaign that targets teen viewers. The action finds a teenage woman asking for cigarettes at a convenience store counter. When the clerk asks for more, the woman begins to pull skin from her alluding to the damage that cigarettes can inflict. KILT Studios manipulated the Skin pull and the replaced the side of her face from the prosthetic application. The skin texture before the pull as well the texture that sits behind her after the pull all were created in post.

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            • FDA Bully

              00:30

              from Kilt Studios / Added

              "A Bullying Cigarette Goes on a Tear" ^ The Food and Drug Administration (FDA) Chose to Personify Tobacco Wrapped in Paper as a Trash-Talking Jerk of a Human. Point Taken! VISUAL CHALLENGE Picture it: a cigarette personified as a four-inch bully of a human. In this memorable Anti-Smoking campaign produced through the FDA, an unkempt, vulgar and demanding man attempts to bully teenagers into smoking. In reality, this man was 6-feet-1 so Kilt Studios scaled him down to a tiny four inches. Scaling a human down is always tricky. The scale always needs to be agreed upon before a shoot since the position of the resulting person and any props will be based on that scale. With this in mind, the Kilt Studios team and the client’s art department worked in unison to ensure the scale was common throughout. VISUAL SOLUTION The background plates for the bully shots were handled first. The position of camera and bully were hero-based for those particular shots. Kilt Studios then derived the resulting Bully lens and camera position based on the background plates. After each shoot day, the Kilt team took the script notes and developed a shooting methodology for the next day where the bully was being shot against the blue screen. Though the camera couldn’t be pushed back as far as hoped, a change of lens accommodated the distance and proper lens distortion was added on the plate in post. Also a concern, the motion of the camera never quite matched from background to foreground as the Kilt team and production didn’t have time and space to physically accommodate for motion control. As a result, matching the speed, tracking between camera moves and scaling all on the context of a large to scaled object was quite difficult. Despite the challenges, the Kilt Studios team worked tirelessly to make sure the resulting images were delivered with the most realistic aesthetic possible. With painstaking effort, the team integrated shadows, and tracked them to the motion of the talent while making sure they properly wrapped around a finger, a door and books. The details of the shadows completely unified the images of background and foreground. The resulting image is obviously affected but exhibits properties of a realistic-looking scene. A mean one at that! MEMORABLE MOMENT There can be a lot of truth in casting. The Bully didn’t have to vere to far to find his character. – maybe mean. Or – when the cafeteria became the shooting stage dressed in blue screen end to end, we knew we had made it. VFX ARTIST Andy Mac, Todd Mesher, Fernando de Souza, Andy Edwards, Patrick Sullivan AGENCY Draft FCB CLIENT FDA SKILLS Second Unit Direction, Compositing, 3D smoke Word count: Approximately 365

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              • FDA Teeth

                00:30

                from Kilt Studios / Added

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                • Movie Preview Show February Week 4

                  05:58

                  from Launching Films / Added

                  10 Plays / / 0 Comments

                  Movie Preview Show February Week 4

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                  • Personalized Revolution: Not Just for Pre-selection Markers by Kelly Constable, Amgen

                    08:42

                    from PMWC Intl / Added

                    92 Plays / / 0 Comments

                    Speaker: Kelly Constable, Business Innovation Lead, Amgen

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                    • Patient, Disease & Drug Profiling Inform Patient Therapeutic Management by Maureen Cronin, Celgene

                      08:04

                      from PMWC Intl / Added

                      61 Plays / / 0 Comments

                      Speaker: Maureen Cronin, Ph.D., Executive Director, Strategic Information Management, Celgene Corporation Personalized Medicine’ initially focused on single or minimal sets of biomarkers to identify patient responders to specific drug therapies. Identifying EGFR mutation profiles for TKIs, BRAF V600E mutations for vemurafenib or EML4-ALK translocation for cizotinib were heralded as major advances in tailored therapy. In reality, emerging science tells us these are exceptions, not the rule. This session will focus on building comprehensive molecular models of disease and exploring how mapping models of drug activity onto these models may give sustainable impetus to precision medicine. Effective therapeutic management will require understanding the patient status with respect to disease context.

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