1. Viracept

    00:56

    from Edgar Meyer Added 6 0 0

    Viracept (Saquinavir, Invirase) was designed on the basis of the structure the depicted enzyme, which mediates maturation of viral particles. When Viracept became available in 1995, the death rate from AIDS fell precipitously: http://www.nigms.nih.gov/Education/structure_drugs.htm Moreover, this historical event proved the undisputed merit of Structure-based Drug Design. Here, the enzyme is depicted as a bronze sculpture in the Grand Canyon. The video demonstrates how a sculpture of a molecule would appear in a public space.

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    • Saquinavir-1ohr

      00:58

      from Edgar Meyer Added 5 0 0

      Viracept (Saquinavir, Invirase) was designed on the basis of the structure the target enzyme, which mediates maturation of viral particles. When Viracept became available in 1995, the death rate from AIDS fell precipitously: http://www.nigms.nih.gov/Education/structure_drugs.htm Moreover, this historical event proved the undisputed merit of Structure-based Drug Design.

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      • Live Cell Imaging of Retroviral Entry: Video 1

        00:12

        from Annual Reviews Added

        A video from the 2014 review by Amy E. Hulme and Thomas J. Hope, "Viral Manipulation of Plant Host Membranes," from the Annual Review of Virology: http://www.annualreviews.org/doi/abs/10.1146/annurev-virology-031413-085502?utm_source=vimeo&utm_medium=vi.hulme&utm_campaign=suppvideo Detection of viral fusion with live cell imaging. The fusion of Tomato-Vpr/iGFP-labeled HIV-1 with CHO cells was imaged at 37°C under a blood/gas mixture of CO2 on a DeltaVision OMX microscope. The experiment was imaged for 44 min with a Z series of images taken every 45 s. Viral fusion was observed as a decrease in GFP fluorescence after 37.5 min due to release of the fluid phase GFP marker into the cytoplasm of the cell. The Tomato-Vpr-labeled virus retained a lower amount of GFP fluorescence after fusion due to GFP localization to the interior of the capsid (Figure 1). See Figure 2 for further details.

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        • Interferon Therapy for HIV-1 Patients: Short Version

          01:02

          from The Wistar Institute Added 104 0 0

          Luis Montaner, D.V.M., D.Phil., announced the results of a clinical trial that suggests interferon can help suppress HIV-1 levels in patients who have suspended their routine antiretroviral therapy. (1.02 minutes)

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          • Interferon Therapy in HIV-1 Patients: Detailed Version

            05:14

            from The Wistar Institute Added 75 0 0

            Luis Montaner, D.V.M., D.Phil., explains the results of a clinical trial trial that suggests interferon can help suppress HIV-1 levels in patients who have suspended their routine antiretroviral therapy. (5:14 min.)

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            • Epidemiology of KSHV in HIV-1-infected US persons in the Era of Combination Antiretroviral Therapy

              04:57

              from Leidos Biomedical Research, Inc. Added 182 0 0

              Nazzarena Labo, Wendell Miley, Constance A. Benson, Thomas B. Campbell and Denise Whitby. Epidemiology of Kaposi’s sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy. AIDS. 2015;29(10): 1217-1225

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              • 1OHR - target for the design of antiviral drugs

                00:52

                from Edgar Meyer Added 7 0 0

                Viracept=Saquinavir was designed on the basis of the structure of this enzyme, which mediates maturation of viral particles. Upon its availability beginning in 1995, the death rate from AIDS fell precipitously: http://www.nigms.nih.gov/Education/structure_drugs.htm Moreover, this historical event proved the undisputed merit of Structure-based Drug Design. Here, the enzyme is depicted as a bronze sculpture in the Grand Canyon.

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