1. Special lecture: Shelly C. Lu, PhD - What’s new about MAT Genes and SAMe?


    from CIC bioGUNE Bilbao / Added

    66 Plays / / 0 Comments

    Methionine adenosyltransferase (MAT) is the sole enzyme responsible for the biosynthesis of S-adenosylmethionine (SAMe), the principal biological methyl donor, precursor of polyamines and in the liver, precursor of glutathione. In mammals, two different genes, MAT1A and MAT2A, encode for two homologous MAT catalytic subunits, 1 (forms either a dimer MAT III, or tetramer MAT I) and 2 (MAT II); while a third gene MAT2B, encodes for a regulatory subunit  that regulates MAT II. Normal differentiated liver expresses MAT1A while all extrahepatic tissues express MAT2A. MAT2A is induced in the liver during periods of rapid growth and dedifferentiation. In human hepatocellular carcinoma (HCC), MAT1A expression is reduced while MAT2A and MAT2B are induced facilitating cancer cell growth. Patients with cirrhosis have decreased MAT1A expression and inactivation of MAT I/III, culminating in decreased SAMe biosynthesis. The consequences of chronic hepatic SAMe depletion are best illustrated by the Mat1a knockout (KO) mouse model, which is characterized by increased susceptibility to steatosis and oxidative liver injury, spontaneous development of steatohepatitis and HCC. Many signal transduction pathways are altered that contribute to HCC formation in this model. These studies illustrate involvement of SAMe in numerous cellular processes; some may be independent of methylation. SAMe has been shown to be chemopreventive against HCC in rodents fed different carcinogens. Part of this may be to prevent carcinogen-induced hepatic SAMe depletion and hypomethylation. In addition, SAMe is selectively pro-apoptotic in liver cancer cells and has anti-angiogenic properties. This should make SAMe an attractive agent for both chemoprevention and treatment of HCC. However, when tested in an in vivo HCC model, SAMe is effective in preventing HCC establishment but not as a treatment of already established HCC because the liver has compensatory mechanisms to prevent accumulation of SAMe to supraphysiologic levels. An alternate and more effective strategy is to enhance MAT1A expression in HCC. Although MAT genes are best known for SAMe biosynthesis, the fact that all three MAT genes are also found in the nucleus raises the possibility that they participate in other pathways. Indeed, MAT2B variants interact with HuR to influence its intracellular location and expression of HuR targets. Taken together, accumulating evidence show SAMe is more than just a methyl donor and MAT genes may participate in SAMe-independent intracellular processes.

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    • Love Your Liver


      from SDARM / Added

      78 Plays / / 1 Comment

      Presented by Susan Lausevic, a certified Health Trainer, at a health program at Schofields, Sydney in 2012

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      • Inside the Doctors Bag, Where is my Appendix?


        from YogaHub / Added

        It has occurred to me that many people do not really know the general location of most of the organs and structures of the body. In this episode we will take a general tour from the skin to within. With this knowledge it might help to figure out certain physical problems.

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        • The Medical Guide


          from YogaHub / Added

          Searching the healthcare Galaxy with the Medical Guide, Dr. Glenn Wollman

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          • The Amazing Liver Gallbladder Flush (Patrick Timpone interviews Andreas Moritz)


            from Andreas Moritz / Added

            Interview with Andreas Moritz – Natural Healer – Author of thirteen books including “The Amazing Liver and Gallbladder Flush”. Hear Andreas make an eloquent argument why we all absolutely need to flush our livers to rid ourselves of stones – and most of us have several thousand. Also hear about the fascinating ability of the to cure cancer, and much more For your copy of the book please click here http://www.ener-chi.com/book.htm#liver

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            • Alpha-1 Antitrypsin Deficiency 101: Lungs & Liver by Kyle Hogarth, MD


              from Alpha-1 Foundation / Added

              160 Plays / / 0 Comments

              2014 National Education Conference Friday, June 6, 2014 Kansas City, KS Speaker: Kyle Hogarth, MD, Assistant Professor, Director of CRC, Director of Cardiopulmonary Rehabilitation, University of Chicago, Department of Medicine and Critical Care

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              • The Gray Zone in Liver Transplantation


                from FCME / Added

                15 Plays / / 0 Comments

                Speaker: Paul Y. Kwo, MD Recorded on 4/15/2009 Objectives: 1. Identify limits of our medical diagnostic tools in diagnosing substance abuse disorders. 2. Explain the allocation of scarce resources in patients with end stage Liver Disease. 3. Explore potential differences in standards for pediatric and adult transplantation Please note that this video is for informational purposes only and is not for CE/CME credit. Dr. Kwo is currently Associate Professor of Medicine and Medical Director of Transplantation at the Indiana University School of Medicine. He joined the faculty in 1995 after receiving Gastroenterology and Hepatology training at the Mayo Clinic in Rochester. Since that time, he has distinguished himself in the field of chronic Hepatitis C and has a large practice devoted to current and novel therapies for the treatment of Hepatitis C. He has won multiple awards, both at the university, local, and national level. The Charles Warren Fairbanks Center for Medical Ethics sponsors the Fairbanks Ethics Lecture Series as an educational outreach to physicians and staff of IU Health Partners hospitals and interested others in the central Indiana community. Lectures are free, open to all, and do not require pre-registration. Continuing education credit is offered to physicians, nurses, social workers, and chaplains at no charge, regardless of their institutional affiliation. For additional information about the Charles Warren Fairbanks Center for Medical Ethics, please visit our website at www.fairbankscenter.org.

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                • Dr Ronald Salem- ANATOMICAL SURGERY OF THE LIVER


                  from YALE MED VIDEO SESSIONS / Added

                  102 Plays / / 0 Comments

                  Ronald Salem, M.D. 53 min 2010

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                  • Alpha-1 Antitrypsin Deficient Liver Disease


                    from Alpha-1 Foundation / Added

                    25 Plays / / 0 Comments

                    2010 Seattle Alpha-1 Education Day October 23, 2010 Speaker: Simon Horslen, MB, Ch.B, Professor of Pediatrics, University of Washington School of Medicine Medical Director, Liver & Intestinal Transplantation, Seattle Children's Hospital

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                    • Supporting Detoxification with Vibrant Blue Essential Oils


                      from Vibrant Blue Oils / Added

                      79 Plays / / 0 Comments

                      Support your detoxification efforts with Vibrant Blue Essential Oils

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